"HGH is large, fragile protein molecule with a molecular weight of 20,000. It contains 191 amino
acids in an exact sequence. Its only source is from human genes, using very expensive and
meticulous recombinant DNA technology.
USING PATENTED TECHNOLOGY, THE PHARMACEUTICAL INDUSTRY HAS DEVELOPED WAYS
TO PARTIALLY ABSORB SOME DRUGS THROUGH THE SKIN. BUT ONLY FOR SMALL, NON-PROTEIN
MOLECULES. INSULIN IS A PROTEIN MOLECULE ONLY HALF AS LARGE AS HGH. IF IT WERE POSSIBLE TO
ABSORB THAT KIND OF HORMONE BY MOUTH, BY SPRAY, OR THROUGH MEMBRANES, MILLIONS OF
PEOPLE WITH DIABETES WOULD NOT NEED TO TAKE INSULIN BY INJECTION. THE MILLIONS OF DOLLARS
SPENT ON RESEARCH TO DO JUST THAT HAS BEEN UNSUCCESSFUL.
A protein molecule that large cannot penetrate intact membranes to any significant degree. Most
would be wasted if it were used in a nasal spray or orally. Manufacturing costs are high. HGH is so
expensive that any waste is prohibitively expensive.
The HGH molecule loses potency very rapidly when dissolved in solution. The molecule is folded
and twisted on itself repeatedly. Activity in the body depends on fragile cross linkages between
branches of this very large molecule, which hold it in an exact three-dimensional configuration. It
works on cell receptors exactly like a key in a lock. Any change in shape blocks HGH activity, even
if the chemical formula remains exactly the same. Those cross-linkages break very easily and
become unstable soon after dissolving in solution. Only with refrigeration can biological activity
be maintained for up to two weeks. That's how fragile the molecule is. How then could activity be
maintained in a liquid spray?
For storage and shipping, HGH must be very carefully freeze-dried under a vacuum to become a
powder. Even the powder must also be kept refrigerated to maintain activity for more than a few
months. Very large pharmaceutical companies with research budgets in the billions of dollars have
not been able to solve that problem.
Dr. Elmer M. Cranton, MD - Mt. Rogers Clinic, Inc.
None of the companies selling various HGH products have disputed these facts. In fact, they acknowledge
the problems associated with the oral delivery of Human Growth Hormone, and address the issue in this way:|
"BioGevity contains a microdilution of biologically active and bioavailable growth hormone encapsulated in a
specialized polymer matrix to protect the growth hormone as it is absorbed through the oral mucosa (the
mouth). The polymer matrix is essential because it enables the growth hormone molecule - normally too large
to penetrate the oral mucosa by merit of its 191 bulky amino acids - to elongate and squeeze through oral
membrane. This matrix allows the hormone to remain intact as it is absorbed into the circulatory system."|
We have asked publicly for any of the above companies to provide us with any information they might have regarding the mysterious "polymer matrix formula", but not a single company has
responded with any information whatsoever. We have written directly to several of the companies requesting any conceivable explanation or scientific data which would explain in even the vaguest
theoretical terms how this "polymer matrix formula" defies the rules of all known science, but have gotten no response.|
We then went outside the network marketing loop, seeking out other companies, scientists, schools, labs, and universities which might have knowledge of or experience with
this exotic HGH hormone delivery system.
Here are excerpts from some of the correspondence we have received:
I am not aware of any system that can do this. There may be enhancers
available in someone's research that has not been published or put into a
patent. The oral spray product could be a fine powder that is absorbed.|
I think most of what you are hearing is marketing. Someone would have to
show hard evidence that any large molecule like HGH gets through the GI
tract and I have not seen it.|
Dr. Robert Langer
I have on occasion read about polymer matrix systems which can deliver
relatively large protein molecules, but I lack the knowledge to tell you
whether such molecules can be delivered directly into the blood stream
without damage to the molecule. I have not heard of a sublingual
delivery system, but this certainly does not mean that they don't exist.|
As for a chewable tablet, again I don't really know. The stomach can
certainly absorb proteins, but I guess, based on what you describe, that
the digestive system would damage your fragile HGH molecule, unless it
was protected in some way. I would have thought that anything released
directly into the mouth would be swallowed before it had time to be
If the products you describe are "real" pharmaceuticals, I
would also have thought that they would have undergone properly
controlled medical trials and studies, which would have been published
in the appropriate medical journals.
Dr. Paul Steward
We found a couple of relevant and interesting research papers or reports on the general topic of polymer
drug delivery systems, but they all dealt with either the controlled release of a substance or were a means of protecting the
drug until it arrived at the required site. We were unable to locate any scientific references to the use of polymers in delivering
large molecule substances through otherwise inaccessible sites.
Polymers have gained in importance in the pharmaceutical industry as both drug encapsulants and vehicles of drug
carriage: either protecting an active agent during its passage through the body (or in storage by preventing moisture
ingress [Udeala & Aly (1989)]) until its release, or controlling its release. A conventional (e.g., sugar) tablet coating has
the disadvantageous side effect of delivering what may be an initially too high and, hence, harmful, dose of active agent
(typically, drug is rapidly released from its dosage form, reaching a maximum concentration, which then decays
exponentially until the next administration), to regions of the body where the drug may not be at its most effective; when
the general aim of any medication is to generate a response in a specific area or organ of the body requiring treatment.|
Review of Pharmaceutical Controlled
Release Methods and Devices.
This article looked promising at first, and seemed to be headed in the right direction:
Professor Langer found that if you put a protein in the polymer matrix in a certain way, it leaves behind pores that would allow even
the biggest molecules to pass through. What's more, with a little jiggering, you could get the molecules to pass through when they
Langer reviews polymer drug-delivery work in Killian Lecture
But as we read on, it soon became obvious that this research did not deal
with the type of large molecule sublingual delivery which these HGH products were claiming to use.|
We also found a few other
references which were extremely interesting and educational regarding the use of polymers for controlled drug
delivery, but nothing even remotely relevant to the delivery of "growth hormone encapsulated in a specialized polymer matrix to protect the growth hormone as it
is absorbed through the oral mucosa (the mouth)."
Dr. Langer's research dealt with the safe delivery and controlled release of large molecule drugs to various parts of the body, not the use of polymers to slip
large HGH molecules through normally unavailable sites. Later correspondence with Dr. Langer confirmed this. Another article discussed some of the
developments in this field over the past 25 years:|
Since Langer began his work in 1974, genetic engineering has made possible
larger and larger macromolecule drugs, such as growth hormones and proteins,
which cannot be taken orally and must therefore be injected. Injections, however,
release drugs into the bloodstream immediately, and many patients are phobic to
needles. Langer found that hydrophobic polymers made it possible to deliver
macromolecular drugs like albumin into the body and at a controlled rate over a
period of time.|
Biomaterials Are Transforming Medicine
Polymer Matrix Formula - Fact or Fraud?
This is the evidence available to all of us. We're going to continue doing additional
research and contacting experts in the field. We'll also continue to contact manufacturers, distributors, and scientists
associated with these various human growth products and give them additional opportunities to present their side of the story.
But after two months of nothing but silence, our considered opinion at this point in time is that the "polymer matrix formula"
is a myth, a fraud, and a scam, right up there with the "Laundry CD" and its infamous "structured water".|
And if the polymer matrix
formula is simply another version of the "Emperor's New Clothes", then any and all of the products claiming to contain and deliver
any version of human growth hormone are also scams!
|And we think it's about time
somebody stands up in this crowd and says so!
Your comments and opinions are welcomed.
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